Finishing his Major League Baseball career with a breathtaking 4,875 strikeouts, Randy Johnson is one of the best pitchers of all time. His milestone 4,000th strikeout. His milestone 4,000th punch out came in a meeting between Johnson's Diamondbacks and the San Diego Padres, in which he collected eight strikeouts. Unfortunately, the Diamondbacks would go on to lose the game, 3-2, despite Johnson allowing just four hits.